EHMT1-IT1: A Potential Drug Target for DNA Double-Strand Break Repair

Target Name: EHMT1 intronic transcript 1

NCBI ID: G643210

EHMT1 intronic transcript 1

Other Name(s): EHMT1-IT1

EHMT1-IT1: A Potential Drug Target for DNA Double-Strand Break Repair

EHMT1 (endonuclease II member 1) is a non-coding RNA molecule that plays a crucial role in regulating DNA double-strand break repair in various organisms, including humans. The intronic transcript of EHMT1, EHMT1-IT1, has been identified and is highly conserved across different species. In this article, we will discuss the EHMT1-IT1 transcript, its potential as a drug target, and its potential implications in the field of molecular medicine.

Structure and Expression

The EHMT1 gene is located on chromosome 16 at position 11.2 kb and has a calculated gene length of 1984 base pairs (bp). The gene encodes a protein with 215 amino acid residues. The protein is composed of a N -terminal alpha-helix, a catalytic domain, and a C-terminal T-loop region. The protein functions as a DNA double-strand break repair enzyme, which is essential for the maintenance of DNA integrity.

The intronic transcript of EHMT1, EHMT1-IT1, is a non-coding RNA molecule that is predominantly expressed in the cytoplasm of HeLa cells. The transcript has a calculated length of 1914 bp and contains 19 exons. The exons are named based on their genomic location, with the first exon containing the 5' end of the transcript and the last exon containing the 3' end. The intronic transcript is poly(A) tailed, which means that the last exon has a poly(A) tail that is extended beyond the 5' end of the transcript.

Function and Potential as a Drug Target

The EHMT1-IT1 transcript is a potential drug target because of its unique function in regulating DNA double-strand break repair. DNA double-strand breaks are often caused by exposure to ionizing radiation, chemical agents, or other forms of stress that can damage the double-strand structure of DNA. Double-strand breaks can lead to genetic mutations, including those that cause diseases such as cancer.

The EHMT1-IT1 transcript functions as a DNA double-strand break repair enzyme. It has been shown to be involved in the repair of various types of DNA double-strand breaks, including homologous and non-homologous ones. The protein encoded by the EHMT1-IT1 transcript can recognize and single-strand break the double-strand break, leading to the formation of a double-strand repair complex.

In addition to its role in DNA double-strand break repair, the EHMT1-IT1 transcript has also been shown to play a role in the regulation of cellular processes, including cell growth, apoptosis, and transcriptional regulation. The protein encoded by the EHMT1-IT1 transcript has been shown to be involved in the regulation of cell adhesion, migration, and the G1/S transition.

Conclusion

In conclusion, the EHMT1-IT1 transcript is a non-coding RNA molecule that plays a crucial role in regulating DNA double-strand break repair in various organisms, including humans. Its unique function as a DNA double-strand break repair enzyme makes it a potential drug target for researchers to study the mechanisms of DNA damage and repair. Further studies are needed to fully understand the role of the EHMT1-IT1 transcript in the regulation of DNA double-strand break repair and its potential as a drug target.

Protein Name: EHMT1 Intronic Transcript 1

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